A Novel Tri-Coordination Zinc Complex Functionalized Silicotungstate with ROS Catalytic Ability and Anti-Tumor Cells Activity

Reactive oxygen species (ROS) can be used as an effective method to treat tumors. Artificial oxidase has received increasing attention a catalyst for ROS generation in fields ranging from bioinorganic chemistry pharmaceutical chemistry. In this study, artificial based on binuclear zinc complex and Keggin-type silicotungstate [Zn2(4,4?-bpy)(Phen)2][SiW12O40] (ZSW) (4,4?-bpy = 4,4?-bipyridine; Phen 1,10-phenanthroline) was synthesized structurally featured terms of its X-ray photoelectron spectrum (XPS), bond valence sum (?s) calculation, IR spectra, single-crystal diffraction (SXRD). ZSW is ionic compound which the cation [Zn2(4,4?-bpy)(Phen)2]4+ anion ?-Keggin-type [SiW12O40]4– cluster. Notably, Zn ions [Zn2(4,4?-bpy)(Phen)2] exist tri-coordination, first obtained polyoxometalate (POM) It also demonstrated that capable efficiently catalyzing production ROS, which, according computational calculations, may due synergistic action complexes POM building blocks. Furthermore, exhibited inhibition ability toward ROS-sensitive tumor cells, such PC12 cells.